Scope of Multivalent Ligand Function: Lactose-Bearing Neoglycopolymers By Ring-Opening Metathesis Polymerization
نویسندگان
چکیده
A lactose-bearing norbornene imide template was polymerized using (Cy3P)2Cl2Ru=CHPh to produce a lactose-substituted neoglycopolymer. The resulting polymer showed a 100-fold overall increase in inhibitory potency (5-fold increase on a per saccharide residue basis) compared to monomeric lactose in both a galectin-binding assay and an Erythrina corallodendrum hemagglutination assay.
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